In 2024, we published The Top 10 AI Concepts Every Scientific R&D Leader Should Know, during the rise of generative AI and LLMs. A lot has changed since then.
As we enter 2026, the conversation is shifting from not only "What insights can AI surface?" to "What can AI autonomously plan, execute, and meaningfully understand about my domain?" To keep your R&D strategy ahead of the curve, here is the updated list of the top 10 AI concepts every leader should know today.
Multimodal AI refers to machine learning models capable of processing and integrating information from multiple types of data. These can include text, images, audio, video, and other forms of input. Unlike traditional models that handle only one data type, multimodal AI combines different inputs to form a more complete representation of a situation or problem.
Nested Learning is a training approach where models learn in layers or levels. Simpler skills are learned first, and more complex abilities are built by combining those earlier learned components. This structure allows AI systems to handle increasingly complex tasks over time.
3. Context Engineering
Context Engineering is the practice of carefully designing the inputs, prompts, and surrounding information that guide AI behavior. The goal is to ensure that AI systems interpret information in the intended way and produce outputs that are relevant and consistent with the situation they are applied to.
Standard AI is effective at finding patterns but can struggle with fixed rules and formal logic. Neuro-Symbolic AI combines neural networks with symbolic systems based on logic and knowledge representation. This approach allows AI to use both learned patterns and rule-based reasoning when generating outputs.
World Models are neural networks that learn how the physical world behaves, like how objects interact and change over time. They simulate real-world dynamics inside a digital environment, allowing AI systems to reason about physical processes rather than relying only on static data.
Horizontal AI systems, like ChatGPT and Gemini, handle general-purpose tasks and can be applied across many domains. They are designed to be broadly useful but are not deeply specialized in any one field.
Vertical AI systems are designed for a specific domain or industry (e.g. materials science R&D). They typically incorporate domain-specific knowledge, data, and workflows which allow them to operate within a highly focused yet strategically deep scope.
Agentic Engineering is about building AI systems that can take actions on their own. Instead of a single model, these systems use multiple AI agents that can plan tasks, use tools, and coordinate with each other.
It builds on ideas popularized by “vibe coding,” where humans describe what they want and AI writes the code. With agentic engineering, the focus shifts from guiding code generation to designing AI agents that can carry out longer sequences of work with minimal human direction.
Physical AI refers to AI systems that operate in the physical world through machines or devices. These systems combine perception, reasoning, and action so that equipment can respond to changes in their environment rather than following only pre-programmed instructions.
Mechanistic Interpretability Tools are methods and software used to analyze how an AI model arrives at its outputs. These tools aim to reveal internal processes and representations inside the model which helps users move beyond treating AI as a black box.
In 2024, our list concluded with Artificial General Intelligence (AGI). AGI is a theoretical form of AI with broad reasoning and learning abilities comparable to a human’s across many domains. While major research organizations remain focused on AGI, there is increasing discussion of a further hypothetical stage known as Artificial Super Intelligence (ASI).
ASI is defined as intelligence that would exceed human cognitive abilities across all areas. It is characterized by faster processing, greater complexity of reasoning, and the ability to improve its own performance with minimal human input. ASI remains speculative and does not currently exist.
For the C-suite and IT, a pressing risk in 2026 is Shadow AI. This refers to the use of unauthorized or unmanaged AI tools by employees, ranging from general LLMs to new viral tools like OpenClaw. To protect intellectual property, leaders must provide secure, enterprise-grade alternatives that allow researchers to innovate without the risk of proprietary data leaking into public models.
For R&D leaders, the goal is no longer just adopting AI but designing and building an AI-driven infrastructure for the next era of scientific discovery.
At Enthought, we help science-driven companies bridge the gap between AI possibilities and R&D reality. If you're ready to explore how to accelerate your R&D pipeline, contact us today.